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KMID : 0608520090150030093
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Korean Journal of Oriental Medicine
2009 Volume.15 No. 3 p.93 ~ p.98
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Acute Toxicity Study on Fermented Yukmijihwangtang Extract in Mice
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Park Hwa-yong
Lee Ji-Hye
Cho Chang-Won
Ma Jin-Yeul
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Abstract
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In this research, the acute toxicity of fermented Yukmijihwangtang extract was examined using male and female ICR mice, To evaluate the acute toxity and safety, 0(control group), 1250, 2500 and 5000 ㎎/㎏ of fermented Yukmijihwangtang extract were orally administered to male and female ICR mice. After single administration, we observed survival rates, general toxicity, changes of body weight for the 14 days and autopsy at 1 day following the administration according to the Regulation of Korean Food and Drug Administration. Compared with the control group, we could not find any toxic alteration in all treated groups (1250, 2500 and 5000 ㎎/㎏). LD?? of fermented Yukmijihwangtang extract might be over 5000 ㎎/㎏ and it is very safe to ICR mice.
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KEYWORD
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Yukmijihwangtang, Fermentation, Acute toxicity, Safety, LD??
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